Synthesis and Pharmacological Activities of Hydrazones, Schiff and Mannich Bases of Isatin Derivatives.
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چکیده
منابع مشابه
Synthesis and pharmacological activities of hydrazones, Schiff and Mannich bases of isatin derivatives.
Schiff bases and phenyl hydrazone of isatins were prepared by reacting isatin and the appropriate aromatic primary amine/hydrazines. A new series of the corresponding N-mannich bases were synthesized by reacting them with formaldehyde and diphenylamine. The chemical structures were confirmed by means of their 1H-NMR, IR spectral data and elemental analysis. The compounds were screened for analg...
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Schiff bases of isatin with aminothiazole, its N-mannich bases and Spiro isatin derivatives were synthesized. Their chemical structures were confirmed by Infrared, 1H-Nuclear Magnetic Resonance data and elemental analysis. Antimicrobial evaluation was performed by the agar diffusion method against four pathogenic bacteria and two pathogenic fungi. Anti-inflammatory activity was tested by carrag...
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Ethyl imidate hydrochlorides 1 were prepared by passing HCl gas through solutions of substituted benzyl cyanides and absolute ethanol. Ethoxycarbonylhydrazones 2 were synthesized from the reaction of compounds 1 with ethyl carbazate. Treatment of 2 with hydrazine hydrate leads to the formation of substituted 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones 3. Isatin and 5-chloroisatin were added to...
متن کاملSynthesis of some isatin Schiff bases in microwave irradiation condition
An efficient and mild methodology for rapid and efficient synthesis of isatin Schiff bases was described under microwave irradiation and solvent free condition.aromatic or heterocyclic Primary amines and isatin could be selectively reacted under microwave irradiation into the corresponding isatin Schiff bases in high yields and short reaction time.
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2001
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.24.1149